Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in pituicytes/fscs | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 110 | 0.82 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4223
Sealed predictions
- CHN1 in dopamine neurons, braak+0.04 (p 0.924) → +0.08 (p 0.839)receipt 4230
Swarm cases
receipt 4230: CHN1 in dopamine neurons, braak
- power
- full sample +0.57 (p 0.014, n 18), 95% CI +0.14 to +0.82. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.58 (p 0.011, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.63 (p 0.0049, n 18). not the mix.
- skeptic
- leave-one-out range +0.51 to +0.65, sign flips 0; without severely affected donors +0.57 (p 0.014, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CHN1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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