Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched, including microglia; strongest in cdc | 0.75 |
| chemistry Open Targets | reachable by antibody: belatacept, abatacept | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 27 Parkinson's papers of 12,554 | 0.56 |
| pathways Reactome | 9 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 7388
Sealed predictions
- CD86 in dopamine neurons, braak+0.45 (p 0.222) → +0.28 (p 0.470)receipt 7397
- CD86 in microglia, braak+0.48 (p 0.186) → -0.66 (p 0.054)receipt 7396
Swarm cases
receipt 7397: CD86 in dopamine neurons, braak
- power
- full sample +0.28 (p 0.254, n 18), 95% CI -0.21 to +0.66. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.28 (p 0.254, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.26 (p 0.302, n 18). could be the mix.
- skeptic
- leave-one-out range +0.20 to +0.40, sign flips 0; without severely affected donors +0.28 (p 0.254, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CD86 in dopamine neurons.
case closed: nothing better to follow up.
receipt 7396: CD86 in microglia, braak
- power
- full sample -0.10 (p 0.702, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.10 (p 0.702, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.07 (p 0.781, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to +0.01, sign flips 2; without severely affected donors -0.10 (p 0.702, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CD86 in microglia.
case closed: nothing better to follow up.
Receipts
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