Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in kupffer cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 119 Parkinson's papers of 16,612 | 0.37 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3460
Sealed predictions
- CD68 in dopamine neurons, braakn/a → n/areceipt 3467
- CD68 in microglia, braak+0.71 (p 0.032) → -0.39 (p 0.295)receipt 3466
In the sealed studies
- An antigen-presenting microglial response: did not hold
Swarm cases
receipt 3467: CD68 in dopamine neurons, braak
- cell type
- CD68 is not measured in dopamine neurons; looking elsewhere.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CD68 in dopamine neurons.
case closed: nothing better to follow up.
receipt 3466: CD68 in microglia, braak
- power
- full sample +0.11 (p 0.676, n 18), 95% CI -0.38 to +0.55. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.13 (p 0.620, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.14 (p 0.573, n 18). could be the mix.
- skeptic
- leave-one-out range -0.02 to +0.25, sign flips 1; without severely affected donors +0.11 (p 0.676, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CD68 in microglia.
case closed: nothing better to follow up.
Receipts
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