Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in nk-cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8453
Sealed predictions
- CCL4L2 in microglia, braak+0.32 (p 0.402) → +0.78 (p 0.014)receipt 8459
- CCL4L2 in dopamine neurons, braak+0.32 (p 0.407) → -0.04 (p 0.911)receipt 8460
Swarm cases
receipt 8460: CCL4L2 in dopamine neurons, braak
- power
- full sample +0.18 (p 0.476, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.24 (p 0.346, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.20 (p 0.424, n 18). could be the mix.
- skeptic
- leave-one-out range +0.07 to +0.30, sign flips 0; without severely affected donors +0.18 (p 0.476, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CCL4L2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 8459: CCL4L2 in microglia, braak
- power
- full sample +0.47 (p 0.047, n 18), 95% CI +0.01 to +0.77. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.31 (p 0.204, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.37 (p 0.135, n 18). could be the mix.
- skeptic
- leave-one-out range +0.41 to +0.58, sign flips 0; without severely affected donors +0.47 (p 0.047, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CCL4L2 in microglia.
case closed: nothing better to follow up.
Receipts
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