Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CCDC88A

coiled-coil and HOOK domain protein 88A

translation score 0.52, read 2026-10-17; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.37 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in late spermatids0.75
chemistry
Open Targets		a small-molecule pocket0.60
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		2 pathways; mostly other0.30

No case: the score is under the bar. Receipt 0741

Sealed predictions

  1. CCDC88A in dopamine neurons, braak+0.39 (p 0.306) → -0.22 (p 0.565)receipt 0748
  2. CCDC88A in oligodendrocytes, braak+0.18 (p 0.644) → -0.03 (p 0.946)receipt 0747

Swarm cases

receipt 0748: CCDC88A in dopamine neurons, braak

power
full sample +0.05 (p 0.854, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.07 (p 0.774, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.365, n 18). could be the mix.
skeptic
leave-one-out range -0.08 to +0.18, sign flips 4; without severely affected donors +0.05 (p 0.854, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CCDC88A in dopamine neurons.

case closed: nothing better to follow up.

receipt 0747: CCDC88A in oligodendrocytes, braak

power
full sample +0.16 (p 0.532, n 18), 95% CI -0.33 to +0.58. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.10 (p 0.696, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.18 (p 0.487, n 18). could be the mix.
skeptic
leave-one-out range +0.05 to +0.31, sign flips 0; without severely affected donors +0.16 (p 0.532, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CCDC88A in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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