Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CBS

cystathionine beta-synthase

translation score 0.41, read 2026-10-21; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.05 from other evidence0.00
cell type
Human Protein Atlas
group enriched, including astrocytes; strongest in bergmann glia0.75
chemistry
Open Targets
a small-molecule pocket0.60
trials
ClinicalTrials.gov
7 Parkinson's trials, 0 stopped1.00
literature
PubMed
384 Parkinson's papers of 11,9030.22
pathways
Reactome
2 pathways; mostly energy0.60

No case: the score is under the bar. Receipt 5239

Sealed predictions

  1. CBS in dopamine neurons, braakn/a → n/areceipt 5248
  2. CBS in astrocytes, braakn/a → n/areceipt 5247

Swarm cases

receipt 5248: CBS in dopamine neurons, braak

cell type
CBS is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CBS in dopamine neurons.

case closed: nothing better to follow up.

receipt 5247: CBS in astrocytes, braak

cell type
CBS is not measured in astrocytes; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CBS in astrocytes.

case closed: nothing better to follow up.

Receipts

loading the receipts