Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 211 Parkinson's trials, 2 stopped | 0.97 |
| literature PubMed | 434 Parkinson's papers of 143,826 | 0.20 |
| pathways Reactome | 5 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 5872
Sealed predictions
- CAT in dopamine neurons, braak-0.20 (p 0.613) → +0.88 (p 0.002)receipt 5879
Swarm cases
receipt 5879: CAT in dopamine neurons, braak
- power
- full sample +0.33 (p 0.176, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.43 (p 0.075, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.42 (p 0.082, n 18). could be the mix.
- skeptic
- leave-one-out range +0.25 to +0.49, sign flips 0; without severely affected donors +0.33 (p 0.176, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CAT in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts