Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

CASP12

caspase 12 (gene/pseudogene)

translation score 0.39, read 2026-10-24; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced outside the brain (lymphatic endothelial cells)0.10
chemistry
Open Targets
compounds already reach it: emricasan0.90
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
2 Parkinson's papers of 2470.85
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 8848

Sealed predictions

  1. CASP12 in dopamine neurons, braakn/a → n/areceipt 8855

Swarm cases

receipt 8855: CASP12 in dopamine neurons, braak

cell type
CASP12 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for CASP12 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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