parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enriched in microglia (23 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	4 Parkinson's papers of 664	0.79
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 10554

CARD9 in dopamine neurons, braak-0.81 (p 0.008) → +0.14 (p 0.724)receipt 10562
CARD9 in microglia, braak-0.02 (p 0.962) → -0.19 (p 0.618)receipt 10561

receipt 10562: CARD9 in dopamine neurons, braak

power: full sample -0.24 (p 0.341, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.24 (p 0.341, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.341, n 18). could be the mix.
skeptic: leave-one-out range -0.42 to -0.14, sign flips 0; without severely affected donors -0.24 (p 0.341, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CARD9 in dopamine neurons.

case closed: nothing better to follow up.

receipt 10561: CARD9 in microglia, braak

power: full sample +0.12 (p 0.633, n 18), 95% CI -0.37 to +0.56. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.11 (p 0.664, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.12 (p 0.640, n 18). could be the mix.
skeptic: leave-one-out range +0.02 to +0.28, sign flips 0; without severely affected donors +0.12 (p 0.633, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for CARD9 in microglia.

case closed: nothing better to follow up.

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