Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.15 (overall 0.09) | 0.15 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 228 | 0.91 |
| pathways Reactome | 1 pathway; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 2839
Sealed predictions
- CAPN10 in dopamine neurons, braak-0.27 (p 0.474) → -0.60 (p 0.089)receipt 2846
Swarm cases
receipt 2846: CAPN10 in dopamine neurons, braak
- power
- full sample -0.46 (p 0.054, n 18), 95% CI -0.76 to +0.01. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.43 (p 0.079, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.50 (p 0.036, n 18). not the mix.
- skeptic
- leave-one-out range -0.56 to -0.39, sign flips 0; without severely affected donors -0.46 (p 0.054, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CAPN10 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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