Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (epididymal principal cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 6 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 613 Parkinson's papers of 100,770: well-trodden | 0.15 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 5650
Sealed predictions
- CAMP in dopamine neurons, braak-0.50 (p 0.173) → -0.26 (p 0.499)receipt 5657
Swarm cases
receipt 5657: CAMP in dopamine neurons, braak
- power
- full sample -0.41 (p 0.093, n 18), 95% CI -0.73 to +0.07. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.41 (p 0.095, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.54 (p 0.019, n 18). not the mix.
- skeptic
- leave-one-out range -0.53 to -0.33, sign flips 0; without severely affected donors -0.41 (p 0.093, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CAMP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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