Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched, including oligodendrocyte progenitor cells; strongest in retinal horizontal cells | 0.75 |
| chemistry Open Targets | compounds already reach it: imagabalin, pregabalin, phloroglucinol +7 | 1.00 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 1 Parkinson's papers of 14 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 5393
Sealed predictions
- CACNG5 in dopamine neurons, braak+0.43 (p 0.251) → -0.26 (p 0.505)receipt 5401
- CACNG5 in oligodendrocytes, braak+0.15 (p 0.702) → -0.34 (p 0.367)receipt 5400
Swarm cases
receipt 5401: CACNG5 in dopamine neurons, braak
- power
- full sample -0.07 (p 0.781, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.10 (p 0.690, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.16 (p 0.532, n 18). could be the mix.
- skeptic
- leave-one-out range -0.18 to +0.05, sign flips 4; without severely affected donors -0.07 (p 0.781, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CACNG5 in dopamine neurons.
case closed: nothing better to follow up.
receipt 5400: CACNG5 in oligodendrocytes, braak
- power
- full sample -0.12 (p 0.633, n 18), 95% CI -0.56 to +0.37. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.11 (p 0.671, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.24 (p 0.341, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to +0.01, sign flips 1; without severely affected donors -0.12 (p 0.633, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for CACNG5 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
loading the receipts