Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.33 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in retinal bipolar cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1014
Sealed predictions
- BRSK2 in dopamine neurons, braak-0.47 (p 0.197) → -0.69 (p 0.042)receipt 1021
Swarm cases
receipt 1021: BRSK2 in dopamine neurons, braak
- power
- full sample -0.43 (p 0.075, n 18), 95% CI -0.75 to +0.05. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.44 (p 0.064, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.027, n 18). not the mix.
- skeptic
- leave-one-out range -0.56 to -0.35, sign flips 0; without severely affected donors -0.43 (p 0.075, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BRSK2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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