Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.20 (overall 0.12) | 0.20 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 15 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 2319
Sealed predictions
- BRIP1 in dopamine neurons, braak+0.63 (p 0.068) → +0.59 (p 0.096)receipt 2325
Swarm cases
receipt 2325: BRIP1 in dopamine neurons, braak
- power
- full sample +0.63 (p 0.0053, n 18), 95% CI +0.23 to +0.85. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.61 (p 0.0077, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.60 (p 0.0083, n 18). not the mix.
- skeptic
- leave-one-out range +0.57 to +0.76, sign flips 0; without severely affected donors +0.63 (p 0.0053, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BRIP1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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