Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: birabresib, ro-6870810, pelabresib +3 | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 3,627 | 0.82 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 9944
Sealed predictions
- BRD4 in dopamine neurons, braak-0.37 (p 0.324) → -0.26 (p 0.502)receipt 9952
Swarm cases
receipt 9952: BRD4 in dopamine neurons, braak
- power
- full sample -0.37 (p 0.127, n 18), 95% CI -0.72 to +0.11. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.38 (p 0.123, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.028, n 18). not the mix.
- skeptic
- leave-one-out range -0.58 to -0.30, sign flips 0; without severely affected donors -0.37 (p 0.127, n 18). fragile.
- cell type
- strongest in OPCs: -0.68 (p 0.0017, n 18) vs -0.37 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BRD4 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up BRD4 · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.10 p 0.722 (needs p < 2.2e-4)
Receipts
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