Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 28 Parkinson's papers of 23,337 | 0.56 |
| pathways Reactome | 28 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 6145
Sealed predictions
- BRCA1 in dopamine neurons, braak-0.37 (p 0.329) → +0.32 (p 0.407)receipt 6153
Swarm cases
receipt 6153: BRCA1 in dopamine neurons, braak
- power
- full sample +0.06 (p 0.820, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.06 (p 0.800, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.04 (p 0.888, n 18). could be the mix.
- skeptic
- leave-one-out range -0.08 to +0.18, sign flips 4; without severely affected donors +0.06 (p 0.820, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BRCA1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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