Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket: svn53-67/m57-klh peptide vaccine, gataparsen | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 1,399 | 0.82 |
| pathways Reactome | 10 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 10135
Sealed predictions
- BIRC5 in dopamine neurons, braak+0.26 (p 0.493) → -0.23 (p 0.554)receipt 10141
Swarm cases
receipt 10141: BIRC5 in dopamine neurons, braak
- power
- full sample -0.06 (p 0.820, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.07 (p 0.794, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.04 (p 0.888, n 18). could be the mix.
- skeptic
- leave-one-out range -0.21 to +0.03, sign flips 4; without severely affected donors -0.06 (p 0.820, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BIRC5 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts