Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

BHLHE22

basic helix-loop-helix family member e22

translation score 0.35, read 2026-10-20; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.06 from other evidence0.00
cell type
Human Protein Atlas
group enriched outside the brain (retinal amacrine cells)0.10
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 4705

Sealed predictions

  1. BHLHE22 in dopamine neurons, braakn/a → n/areceipt 4710

Swarm cases

receipt 4710: BHLHE22 in dopamine neurons, braak

cell type
BHLHE22 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for BHLHE22 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

loading the receipts