Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.24 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched, including brain inhibitory neurons; strongest in ependymal cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 282 | 0.85 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1779
Sealed predictions
- BBS1 in dopamine neurons, braak-0.05 (p 0.894) → -0.14 (p 0.714)receipt 1785
Swarm cases
receipt 1785: BBS1 in dopamine neurons, braak
- power
- full sample -0.10 (p 0.696, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.13 (p 0.609, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.08 (p 0.767, n 18). could be the mix.
- skeptic
- leave-one-out range -0.23 to +0.01, sign flips 1; without severely affected donors -0.10 (p 0.696, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BBS1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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