Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 5 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 868 Parkinson's papers of 60,970: well-trodden | 0.11 |
| pathways Reactome | 7 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 4558
Sealed predictions
- BAX in dopamine neurons, braak-0.22 (p 0.563) → -0.32 (p 0.407)receipt 4565
Swarm cases
receipt 4565: BAX in dopamine neurons, braak
- power
- full sample -0.15 (p 0.555, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.17 (p 0.493, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.095, n 18). could be the mix.
- skeptic
- leave-one-out range -0.26 to -0.03, sign flips 0; without severely affected donors -0.15 (p 0.555, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BAX in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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