Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 92 Parkinson's trials, 4 stopped | 0.94 |
| literature PubMed | 203 Parkinson's papers of 46,528 | 0.30 |
| pathways Reactome | 5 pathways; mostly mitochondrial quality control | 1.00 |
No case: the score is under the bar. Receipt 9743
Sealed predictions
- BAD in dopamine neurons, braak+0.00 (p 1.000) → +0.04 (p 0.909)receipt 9749
Swarm cases
receipt 9749: BAD in dopamine neurons, braak
- power
- full sample +0.01 (p 0.962, n 18), 95% CI -0.46 to +0.48. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.08 (p 0.754, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.11 (p 0.677, n 18). could be the mix.
- skeptic
- leave-one-out range -0.10 to +0.12, sign flips 6; without severely affected donors +0.01 (p 0.962, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for BAD in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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