Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.53 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (extravillous trophoblasts) | 0.10 |
| chemistry Open Targets | compounds already reach it: ibcasertib, barasertib, cyc-116 +15 | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 796 | 0.91 |
| pathways Reactome | 10 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 11472
Earlier readings: 2026-10-26 0.52; 2026-10-25 0.52; 2026-10-24 0.52; 2026-10-23 0.52.
Sealed predictions
- AURKB in dopamine neurons, braak-0.04 (p 0.927) → -0.21 (p 0.591)receipt 0181
Swarm cases
receipt 0181: AURKB in dopamine neurons, braak
- power
- full sample -0.19 (p 0.450, n 18), 95% CI -0.60 to +0.30. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.18 (p 0.487, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.22 (p 0.384, n 18). could be the mix.
- skeptic
- leave-one-out range -0.31 to -0.09, sign flips 0; without severely affected donors -0.19 (p 0.450, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AURKB in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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