Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

ATXN3L

ataxin 3 like

translation score 0.40, read 2026-10-21; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.05 from other evidence0.00
cell type
Human Protein Atlas
cell type enriched outside the brain (late spermatids)0.10
chemistry
Open Targets
hard to drug0.40
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 4883

Sealed predictions

  1. ATXN3L in dopamine neurons, braakn/a → n/areceipt 4892

Swarm cases

receipt 4892: ATXN3L in dopamine neurons, braak

cell type
ATXN3L is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ATXN3L in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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