Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched in other brain neurons (180 nCPM) | 1.00 |
| chemistry Open Targets | compounds already reach it: acetyldigitoxin, istaroxime, deslanoside +3 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 161 Parkinson's papers of 497 | 0.33 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2992
Sealed predictions
- ATP1A3 in dopamine neurons, braak-0.40 (p 0.285) → +0.06 (p 0.877)receipt 2999
Swarm cases
receipt 2999: ATP1A3 in dopamine neurons, braak
- power
- full sample -0.19 (p 0.444, n 18), 95% CI -0.60 to +0.30. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.24 (p 0.346, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.145, n 18). could be the mix.
- skeptic
- leave-one-out range -0.29 to -0.08, sign flips 0; without severely affected donors -0.19 (p 0.444, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ATP1A3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts