Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in myonuclei | 0.75 |
| chemistry Open Targets | compounds already reach it: digoxin, deslanoside, lanatoside c +3 | 1.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 10 Parkinson's papers of 430 | 0.69 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 5799
Sealed predictions
- ATP1A2 in dopamine neurons, braak-0.14 (p 0.722) → -0.44 (p 0.233)receipt 5809
- ATP1A2 in astrocytes, braak+0.04 (p 0.928) → +0.05 (p 0.907)receipt 5808
Swarm cases
receipt 5809: ATP1A2 in dopamine neurons, braak
- power
- full sample -0.26 (p 0.294, n 18), 95% CI -0.65 to +0.23. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.25 (p 0.315, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.25 (p 0.323, n 18). could be the mix.
- skeptic
- leave-one-out range -0.40 to -0.19, sign flips 0; without severely affected donors -0.26 (p 0.294, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ATP1A2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 5808: ATP1A2 in astrocytes, braak
- power
- full sample +0.03 (p 0.894, n 18), 95% CI -0.44 to +0.49. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.05 (p 0.847, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.03 (p 0.901, n 18). could be the mix.
- skeptic
- leave-one-out range -0.10 to +0.18, sign flips 6; without severely affected donors +0.03 (p 0.894, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ATP1A2 in astrocytes.
case closed: nothing better to follow up.
Receipts
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