Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

ATOH1

atonal bHLH transcription factor 1

translation score 0.28, read 2026-10-23; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
genetic association 0.04 (overall 0.03)0.04
cell type
Human Protein Atlas
cell type enriched outside the brain (goblet cells)0.10
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
4 Parkinson's papers of 6430.79
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 7013

Sealed predictions

  1. ATOH1 in dopamine neurons, braakn/a → n/areceipt 7020

Swarm cases

receipt 7020: ATOH1 in dopamine neurons, braak

cell type
ATOH1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ATOH1 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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