parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.31 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in microglia (697 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	2 Parkinson's trials, 0 stopped	1.00
literature PubMed	50 Parkinson's papers of 22,262	0.48
pathways Reactome	28 pathways; mostly dopamine synapse	1.00

No case: the score is under the bar. Receipt 1205

receipt 1214: ATM in dopamine neurons, braak

power: full sample -0.19 (p 0.439, n 18), 95% CI -0.61 to +0.30. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.17 (p 0.493, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.05 (p 0.834, n 18). could be the mix.
skeptic: leave-one-out range -0.35 to -0.09, sign flips 0; without severely affected donors -0.19 (p 0.439, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ATM in dopamine neurons.

case closed: nothing better to follow up.

receipt 1213: ATM in microglia, braak

power: full sample +0.11 (p 0.652, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.18 (p 0.471, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.15 (p 0.561, n 18). could be the mix.
skeptic: leave-one-out range -0.01 to +0.27, sign flips 1; without severely affected donors +0.11 (p 0.652, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ATM in microglia.

case closed: nothing better to follow up.

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