Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 450 | 0.82 |
| pathways Reactome | 1 pathway; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 5433
Sealed predictions
- ATG4B in dopamine neurons, braak-0.32 (p 0.407) → +0.00 (p 1.000)receipt 5441
Swarm cases
receipt 5441: ATG4B in dopamine neurons, braak
- power
- full sample -0.28 (p 0.261, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.26 (p 0.298, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.28 (p 0.258, n 18). could be the mix.
- skeptic
- leave-one-out range -0.36 to -0.17, sign flips 0; without severely affected donors -0.28 (p 0.261, n 18). fragile.
- cell type
- strongest in astrocytes: -0.62 (p 0.0062, n 18) vs -0.28 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ATG4B in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up ATG4B · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.15 p 0.594 (needs p < 3.6e-4)
Receipts
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