Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.40 |
| trials ClinicalTrials.gov | 16 Parkinson's trials, 1 stopped | 0.95 |
| literature PubMed | 88 Parkinson's papers of 6,677 | 0.41 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6540
Sealed predictions
- ASL in dopamine neurons, braak-0.44 (p 0.235) → -0.12 (p 0.767)receipt 6547
Swarm cases
receipt 6547: ASL in dopamine neurons, braak
- power
- full sample -0.44 (p 0.064, n 18), 95% CI -0.75 to +0.03. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.41 (p 0.093, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.51 (p 0.030, n 18). not the mix.
- skeptic
- leave-one-out range -0.53 to -0.38, sign flips 0; without severely affected donors -0.44 (p 0.064, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ASL in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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