parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocyte progenitor cells (106 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 306	0.85
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 8154

receipt 8194: ASIC1 in dopamine neurons, braak

power: full sample -0.12 (p 0.646, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.10 (p 0.690, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.23 (p 0.360, n 18). could be the mix.
skeptic: leave-one-out range -0.20 to +0.02, sign flips 2; without severely affected donors -0.12 (p 0.646, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ASIC1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 8193: ASIC1 in oligodendrocytes, braak

power: full sample -0.16 (p 0.532, n 18), 95% CI -0.58 to +0.33. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.13 (p 0.597, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.13 (p 0.609, n 18). could be the mix.
skeptic: leave-one-out range -0.33 to -0.05, sign flips 0; without severely affected donors -0.16 (p 0.532, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ASIC1 in oligodendrocytes.

case closed: nothing better to follow up.

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