Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (parietal cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 43 | 0.82 |
| pathways Reactome | 1 pathway; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 7726
Sealed predictions
- ASAH2 in dopamine neurons, braak+0.71 (p 0.032) → -0.02 (p 0.965)receipt 7733
Swarm cases
receipt 7733: ASAH2 in dopamine neurons, braak
- power
- full sample +0.42 (p 0.084, n 18), 95% CI -0.06 to +0.74. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.44 (p 0.070, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.43 (p 0.074, n 18). could be the mix.
- skeptic
- leave-one-out range +0.34 to +0.60, sign flips 0; without severely affected donors +0.42 (p 0.084, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ASAH2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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