Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.35 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 3 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 18 Parkinson's papers of 2,651 | 0.61 |
| pathways Reactome | 7 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 0875
Sealed predictions
- ARNT in dopamine neurons, braak+0.13 (p 0.733) → +0.37 (p 0.334)receipt 0882
Swarm cases
receipt 0882: ARNT in dopamine neurons, braak
- power
- full sample +0.32 (p 0.194, n 18), 95% CI -0.17 to +0.69. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.29 (p 0.243, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.38 (p 0.123, n 18). could be the mix.
- skeptic
- leave-one-out range +0.24 to +0.49, sign flips 0; without severely affected donors +0.32 (p 0.194, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ARNT in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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