Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 12 Parkinson's trials, 1 stopped | 0.93 |
| literature PubMed | 105 Parkinson's papers of 37,811 | 0.39 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8156
Sealed predictions
- ARC in dopamine neurons, braak+0.26 (p 0.493) → -0.48 (p 0.188)receipt 8195
Swarm cases
receipt 8195: ARC in dopamine neurons, braak
- power
- full sample -0.03 (p 0.894, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.04 (p 0.888, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.11 (p 0.671, n 18). could be the mix.
- skeptic
- leave-one-out range -0.17 to +0.08, sign flips 5; without severely affected donors -0.03 (p 0.894, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ARC in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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