Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.24 (overall 0.15) | 0.24 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2197
Sealed predictions
- ARAP3 in dopamine neurons, braak-0.40 (p 0.287) → -0.46 (p 0.215)receipt 2202
Swarm cases
receipt 2202: ARAP3 in dopamine neurons, braak
- power
- full sample -0.52 (p 0.026, n 18), 95% CI -0.80 to -0.07. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.53 (p 0.023, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.65 (p 0.0033, n 18). not the mix.
- skeptic
- leave-one-out range -0.68 to -0.46, sign flips 0; without severely affected donors -0.52 (p 0.026, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ARAP3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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