Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: oxandrolone, cr 1447, gsk2849466 +37 | 1.00 |
| trials ClinicalTrials.gov | 75 Parkinson's trials, 8 stopped | 0.87 |
| literature PubMed | 446 Parkinson's papers of 79,927 | 0.20 |
| pathways Reactome | 6 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 5785
Sealed predictions
- AR in dopamine neurons, braak+0.32 (p 0.402) → +0.12 (p 0.767)receipt 5792
Swarm cases
receipt 5792: AR in dopamine neurons, braak
- power
- full sample +0.28 (p 0.261, n 18), 95% CI -0.22 to +0.66. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.54 (p 0.021, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.051, n 18). could be the mix.
- skeptic
- leave-one-out range +0.18 to +0.46, sign flips 0; without severely affected donors +0.28 (p 0.261, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AR in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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