parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.11 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in astrocytes (743 nCPM)	1.00
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	1 Parkinson's trial, 0 stopped	1.00
literature PubMed	93 Parkinson's papers of 5,957	0.40
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 2503

receipt 2511: AQP4 in dopamine neurons, braak

power: full sample +0.11 (p 0.671, n 18), 95% CI -0.38 to +0.55. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.08 (p 0.748, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.10 (p 0.696, n 18). could be the mix.
skeptic: leave-one-out range -0.01 to +0.19, sign flips 3; without severely affected donors +0.11 (p 0.671, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for AQP4 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2510: AQP4 in astrocytes, braak

power: full sample -0.24 (p 0.341, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.27 (p 0.281, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.16 (p 0.515, n 18). could be the mix.
skeptic: leave-one-out range -0.36 to -0.12, sign flips 0; without severely affected donors -0.24 (p 0.341, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for AQP4 in astrocytes.

case closed: nothing better to follow up.

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