Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (hepatocytes) | 0.10 |
| chemistry Open Targets | reachable by antibody: volanesorsen, volanesorsen sodium, olezarsen | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 4 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 8423
Sealed predictions
- APOC3 in dopamine neurons, braak-0.47 (p 0.197) → -0.43 (p 0.253)receipt 8431
Swarm cases
receipt 8431: APOC3 in dopamine neurons, braak
- power
- full sample -0.32 (p 0.191, n 18), 95% CI -0.69 to +0.17. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.34 (p 0.170, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.045, n 18). not the mix.
- skeptic
- leave-one-out range -0.43 to -0.23, sign flips 0; without severely affected donors -0.32 (p 0.191, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for APOC3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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