Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

APOA1

apolipoprotein A1

translation score 0.41, read 2026-10-19; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.10 from other evidence0.00
cell type
Human Protein Atlas
group enriched outside the brain (hepatocytes)0.10
chemistry
Open Targets
a small-molecule pocket0.60
trials
ClinicalTrials.gov
2 Parkinson's trials, 0 stopped1.00
literature
PubMed
32 Parkinson's papers of 3,7370.54
pathways
Reactome
20 pathways; mostly immune signalling0.90

No case: the score is under the bar. Receipt 2709

Sealed predictions

  1. APOA1 in dopamine neurons, braakn/a → n/areceipt 2718

Swarm cases

receipt 2718: APOA1 in dopamine neurons, braak

cell type
APOA1 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for APOA1 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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