parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	group enriched, including astrocytes; strongest in vascular endothelial cells	0.75
chemistry Open Targets	a small-molecule pocket: apelin	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 252	0.82
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 8019

receipt 8026: APLNR in dopamine neurons, braak

power: full sample -0.23 (p 0.355, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.24 (p 0.341, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.26 (p 0.306, n 18). could be the mix.
skeptic: leave-one-out range -0.38 to -0.12, sign flips 0; without severely affected donors -0.23 (p 0.355, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for APLNR in dopamine neurons.

case closed: nothing better to follow up.

receipt 8025: APLNR in astrocytes, braak

power: full sample -0.07 (p 0.787, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.12 (p 0.646, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.12 (p 0.646, n 18). could be the mix.
skeptic: leave-one-out range -0.22 to +0.07, sign flips 4; without severely affected donors -0.07 (p 0.787, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for APLNR in astrocytes.

case closed: nothing better to follow up.

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