parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in astrocytes (739 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	1 Parkinson's trial, 0 stopped	1.00
literature PubMed	37 Parkinson's papers of 33,598	0.52
pathways Reactome	15 pathways; mostly protein handling	0.90

No case: the score is under the bar. Receipt 11690

receipt 11698: APC in dopamine neurons, braak

power: full sample +0.15 (p 0.555, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.14 (p 0.585, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.20 (p 0.429, n 18). could be the mix.
skeptic: leave-one-out range +0.03 to +0.30, sign flips 0; without severely affected donors +0.15 (p 0.555, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for APC in dopamine neurons.

case closed: nothing better to follow up.

receipt 11697: APC in astrocytes, braak

power: full sample +0.18 (p 0.487, n 18), 95% CI -0.32 to +0.59. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.16 (p 0.532, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.14 (p 0.579, n 18). could be the mix.
skeptic: leave-one-out range +0.06 to +0.29, sign flips 0; without severely affected donors +0.18 (p 0.487, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for APC in astrocytes.

case closed: nothing better to follow up.

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