parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in alveolar cells type 1	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 9936

receipt 9946: ANOS1 in dopamine neurons, braak

power: full sample +0.27 (p 0.277, n 18), 95% CI -0.22 to +0.65. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.40 (p 0.103, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.39 (p 0.114, n 18). could be the mix.
skeptic: leave-one-out range +0.16 to +0.41, sign flips 0; without severely affected donors +0.27 (p 0.277, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ANOS1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9945: ANOS1 in microglia, braak

power: full sample +0.31 (p 0.218, n 18), 95% CI -0.19 to +0.68. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.35 (p 0.159, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.36 (p 0.142, n 18). could be the mix.
skeptic: leave-one-out range +0.23 to +0.47, sign flips 0; without severely affected donors +0.31 (p 0.218, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ANOS1 in microglia.

case closed: nothing better to follow up.

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