Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

ANKFN1

ankyrin repeat and fibronectin type III domain containing 1

translation score 0.45, read 2026-10-20; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.06 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including astrocytes; strongest in respiratory ciliated cells0.75
chemistry
Open Targets		hard to drug0.27
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 4521

Sealed predictions

  1. ANKFN1 in dopamine neurons, braak+0.36 (p 0.348) → +0.52 (p 0.154)receipt 4530
  2. ANKFN1 in astrocytes, braak+0.71 (p 0.032) → -0.36 (p 0.347)receipt 4529

Swarm cases

receipt 4530: ANKFN1 in dopamine neurons, braak

power
full sample +0.50 (p 0.033, n 18), 95% CI +0.05 to +0.79. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: +0.49 (p 0.040, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.51 (p 0.029, n 18). not the mix.
skeptic
leave-one-out range +0.44 to +0.58, sign flips 0; without severely affected donors +0.50 (p 0.033, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ANKFN1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 4529: ANKFN1 in astrocytes, braak

power
full sample +0.13 (p 0.597, n 18), 95% CI -0.36 to +0.57. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.12 (p 0.640, n 18). does not hold up.
composition
astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.15 (p 0.555, n 18). could be the mix.
skeptic
leave-one-out range +0.03 to +0.28, sign flips 0; without severely affected donors +0.13 (p 0.597, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ANKFN1 in astrocytes.

case closed: nothing better to follow up.

Receipts

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