Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in ependymal cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 5 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 29 Parkinson's papers of 3,215 | 0.55 |
| pathways Reactome | 1 pathway; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 6481
Sealed predictions
- AMT in astrocytes, braakn/a → n/areceipt 6488
- AMT in dopamine neurons, braak+0.16 (p 0.689) → -0.59 (p 0.096)receipt 6489
Swarm cases
receipt 6489: AMT in dopamine neurons, braak
- power
- full sample -0.30 (p 0.225, n 18), 95% CI -0.67 to +0.19. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.28 (p 0.258, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.43 (p 0.079, n 18). could be the mix.
- skeptic
- leave-one-out range -0.44 to -0.21, sign flips 0; without severely affected donors -0.30 (p 0.225, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AMT in dopamine neurons.
case closed: nothing better to follow up.
receipt 6488: AMT in astrocytes, braak
- cell type
- AMT is not measured in astrocytes; looking elsewhere.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AMT in astrocytes.
case closed: nothing better to follow up.
Receipts
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