Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.07 (overall 0.05) | 0.07 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (enterocytes) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 5 Parkinson's papers of 1,113 | 0.76 |
| pathways Reactome | 4 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 5498
Sealed predictions
- AMN in dopamine neurons, braak-0.45 (p 0.230) → -0.01 (p 0.982)receipt 5505
Swarm cases
receipt 5505: AMN in dopamine neurons, braak
- power
- full sample -0.23 (p 0.355, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.17 (p 0.509, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.25 (p 0.319, n 18). could be the mix.
- skeptic
- leave-one-out range -0.34 to -0.12, sign flips 0; without severely affected donors -0.23 (p 0.355, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AMN in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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