Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody: gsk-2586881 | 0.45 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 5 Parkinson's papers of 3,657 | 0.76 |
| pathways Reactome | 5 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 3641
Sealed predictions
- AGT in dopamine neurons, braak+0.12 (p 0.761) → -0.59 (p 0.098)receipt 3647
Swarm cases
receipt 3647: AGT in dopamine neurons, braak
- power
- full sample -0.16 (p 0.526, n 18), 95% CI -0.58 to +0.33. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.13 (p 0.597, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.10 (p 0.702, n 18). could be the mix.
- skeptic
- leave-one-out range -0.24 to -0.05, sign flips 0; without severely affected donors -0.16 (p 0.526, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for AGT in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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