Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

ADORA1

adenosine A1 receptor

translation score 0.51, read 2026-10-17; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.32 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in podocytes0.75
chemistry
Open Targets		compounds already reach it: t-62, adenosine, caffeine +191.00
trials
ClinicalTrials.gov		31 Parkinson's trials, 4 stopped0.90
literature
PubMed		7 Parkinson's papers of 2270.73
pathways
Reactome		2 pathways; mostly other0.30

No case: the score is under the bar. Receipt 1117

Sealed predictions

  1. ADORA1 in oligodendrocytes, braak-0.39 (p 0.300) → -0.52 (p 0.154)receipt 1123
  2. ADORA1 in dopamine neurons, braak+0.03 (p 0.946) → -0.41 (p 0.273)receipt 1124

Swarm cases

receipt 1124: ADORA1 in dopamine neurons, braak

power
full sample -0.15 (p 0.561, n 18), 95% CI -0.57 to +0.34. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.14 (p 0.579, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.50 (p 0.034, n 18). not the mix.
skeptic
leave-one-out range -0.24 to -0.03, sign flips 0; without severely affected donors -0.15 (p 0.561, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ADORA1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 1123: ADORA1 in oligodendrocytes, braak

power
full sample -0.50 (p 0.035, n 18), 95% CI -0.78 to -0.04. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.49 (p 0.041, n 18). holds up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.57 (p 0.013, n 18). not the mix.
skeptic
leave-one-out range -0.63 to -0.43, sign flips 0; without severely affected donors -0.50 (p 0.035, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for ADORA1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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