Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.09 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (adipocytes) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 3 Parkinson's papers of 1,791 | 0.82 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2883
Sealed predictions
- ADIPOQ in dopamine neurons, braak+0.25 (p 0.514) → +0.03 (p 0.944)receipt 2890
Swarm cases
receipt 2890: ADIPOQ in dopamine neurons, braak
- power
- full sample +0.09 (p 0.722, n 18), 95% CI -0.39 to +0.53. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.11 (p 0.671, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.13 (p 0.597, n 18). could be the mix.
- skeptic
- leave-one-out range +0.00 to +0.24, sign flips 1; without severely affected donors +0.09 (p 0.722, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ADIPOQ in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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