Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.03 (overall 0.02) | 0.03 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in retinal horizontal cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 2 Parkinson's papers of 82 | 0.85 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7307
Sealed predictions
- ADD2 in dopamine neurons, braak+0.61 (p 0.083) → -0.57 (p 0.109)receipt 7315
Swarm cases
receipt 7315: ADD2 in dopamine neurons, braak
- power
- full sample -0.02 (p 0.935, n 18), 95% CI -0.48 to +0.45. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.03 (p 0.915, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.15 (p 0.549, n 18). could be the mix.
- skeptic
- leave-one-out range -0.12 to +0.12, sign flips 6; without severely affected donors -0.02 (p 0.935, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ADD2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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