parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in pituicytes/fscs	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	4 Parkinson's papers of 107	0.79
pathways Reactome	3 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 5274

ADCYAP1R1 in astrocytes, braak-0.42 (p 0.265) → -0.42 (p 0.262)receipt 5281
ADCYAP1R1 in dopamine neurons, braak+0.15 (p 0.699) → -0.09 (p 0.819)receipt 5282

receipt 5282: ADCYAP1R1 in dopamine neurons, braak

power: full sample -0.04 (p 0.861, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.05 (p 0.854, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.29 (p 0.250, n 18). could be the mix.
skeptic: leave-one-out range -0.16 to +0.06, sign flips 5; without severely affected donors -0.04 (p 0.861, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ADCYAP1R1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 5281: ADCYAP1R1 in astrocytes, braak

power: full sample -0.35 (p 0.159, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.36 (p 0.145, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.30 (p 0.221, n 18). could be the mix.
skeptic: leave-one-out range -0.44 to -0.26, sign flips 0; without severely affected donors -0.35 (p 0.159, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ADCYAP1R1 in astrocytes.

case closed: nothing better to follow up.

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