Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.10 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (mast cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 214 | 0.85 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2585
Sealed predictions
- ADCYAP1 in dopamine neurons, braak-0.56 (p 0.118) → +0.11 (p 0.787)receipt 2591
Swarm cases
receipt 2591: ADCYAP1 in dopamine neurons, braak
- power
- full sample -0.06 (p 0.807, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.06 (p 0.827, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.02 (p 0.935, n 18). could be the mix.
- skeptic
- leave-one-out range -0.22 to +0.03, sign flips 4; without severely affected donors -0.06 (p 0.807, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ADCYAP1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts